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Home > PROTEOMICS > ELISA/CLIA/COLORIMETRIC KITS > H u m a n C a s p a s e 8 P i c o K i n e "! E L I S A K i t
H u m a n C a s p a s e 8 P i c o K i n e "! E L I S A K i t
AGGIUNGI AL CARRELLO
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Code | EK1426 |
---|---|
Description | H u m a n C a s p a s e 8 P i c o K i n e "! E L I S A K i t |
Size | 1 x 96T |
General information | Caspase-8 is a caspase protein, encoded by the CASP8 gene. It is mapped to human chromosome 2q33-q34 and mouse chromosome 1B-proximal C. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. And this protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. |
ALTERNATIVE NAME | Caspase-8;CASP-8;3.4.22.61;Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4;FADD-homologous ICE/ced-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MORT1-associated ced-3 homolog;MACH;Caspase-8 subunit p18;Caspase-8 subunit p10;CASP8;MCH5; |
Assay type | complete kit |
Detection method | ELISA |
Sample type | cell culture supernatesand serum. |
Range detection | 31.2pg/ml-2000pg/ml |
Sensitivity | <10pg/ml |
Target species | Human |
Protein id | Q14790 |
Storage | S t o r e a t 4 ÚC f o r 6 m o n t h s , a t - 2 0 ÚC f o r 1 2 m o n t h s . A v o i d m u l t i p l e f r e e z e - t h a w c y c l e s ( S h i p p e d w i t h w e t i c e . ) |
Data sheet | www.bosterbio.com/datasheet.php?sku=EK1426 |
Source | Boster Immunoleader |
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© 1995-2024 temaricerca.com - Tutti i diritti riservati - P.IVA 00674091202
Via XXI Ottobre 1944, 11/2, 40055 Castenaso (BO) - tel: 051 62 40 700 - fax: 051 62 40 706